Skip to main content

Graft-Versus-Host Disease

Laura B. Bishop, MD Reviewed 05/2023
 


BASICS

DESCRIPTION

  • A systemic disorder in allogeneic hematopoietic stem cell transplant (HSCT) recipients caused by donor T cells recognizing host (recipient) antigens as foreign initiating an immune r...

DIAGNOSIS

HISTORY

  • GVHD can affect any organ.

  • Frequent sites include skin, liver and GI organs; skin is often first involved.

    • Additional sites include oral, ocular, pulmonary, and neuromuscular systems.

  • Sy...

TREATMENT

GENERAL MEASURES

  • aGVHD is graded from 0 (absent) to IV (very severe).

  • cGVHD is graded from 0 (mild) to 3 (severe) based on individual organ severity.

MEDICATION

First Line

With aGVHD, first line ...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patients should follow up with their transplant physician, consulting physicians, and supportive care staff. 

Patient Monitoring

  • Nutritional status, including oral ...

REFERENCES

1
Mohamed FA, Thangavelu G, Rhee SY, et al. Recent metabolic advances for preventing and treating acute and chronic graft versus host disease. Front Immunol. 2021;12:757836. doi: 10.3389/fim...

CODES

ICD10

  • D89.813 Graft-versus-host disease, unspecified

  • D89.810 Acute graft-versus-host disease

  • D89.811 Chronic graft-versus-host disease

  • D89.812 Acute on chronic graft-versus-host disease

SNOMED

  • 2346460...

CLINICAL PEARLS

  • aGVHD and cGVHD are defined by clinical manifestations and have separate pathophysiologies. aGVHD occurs early after transplant (< 100 days).

  • Skin, GIT, and liver are the common site...

Subscribe to Access Full Content

Sign Up for a 10-Day Free Trial

Sign up for a 10-day FREE Trial now and receive full access to all content.

×