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Peyronie Disease

Patrick M. Zito, PharmD, DO and Kirin K. Syed, DO, FACOS Reviewed 05/2023
 


BASICS

DESCRIPTION

  • Peyronie disease (PD) is a progressive connective tissue disorder affecting the tunica albuginea.

  • Results in aberrant fibrosis and inelastic scar (plaque) formation due to abnormal wo...

DIAGNOSIS

HISTORY

  • Detailed history including history of trauma, diabetes, hypertension, hypercholesterolemia, tobacco use

  • Duration and onset of symptoms

  • Degree of curvature

  • Ability to penetrate

  • Erectile ca...

TREATMENT

GENERAL MEASURES

  • There are a variety of medical and surgical options for treatment. The paucity of randomized controlled trials (RCTs) makes drawing conclusions difficult, resulting in a lack...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patients should be monitored regularly to assess response to therapy. 

Patient Monitoring

Significant psychological stress and bother can be present in the male and...

REFERENCES

1
Chung  E, Ralph  D, Kagioglu  A, et al. Evidence-based management guidelines on Peyronie’s disease. J Sex Med.  2016;13(6):905–923. [View Abstract on OvidMedli...

SEE ALSO

Erectile Dysfunction 

CODES

ICD10

N48.6 Induration penis plastica 

SNOMED

1335005 Induratio penis plastica (disorder) 

CLINICAL PEARLS

  • PD is characterized clinically by penile pain and curvature caused by fibrotic plaque in the tunica albuginea.

  • An acute active phase of inflammation is followed by a stable chronic phas...

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