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Primary Ovarian Insufficiency

Kirsten R Vitrikas, MD, Amber Sei-Ngai Lau, MPH, DO and Sarah E Miller, MPH, MD Reviewed 05/2023
 


BASICS

DESCRIPTION

  • Primary ovarian insufficiency (POI) describes a spectrum of conditions including hypergonadotropic hypogonadism, premature ovarian failure (POF), and ovarian dysgenesis where there i...

DIAGNOSIS

HISTORY

  • Oligomenorrhea for at least 3 consecutive months Typically, history of normal puberty and menses, although primary amenorrhea and absence of secondary sexual characteristics is presen...

TREATMENT

GENERAL MEASURES

  • Medical treatment should address the patient's hormonal, reproductive, emotional, and psychological needs.

  • Unless there is a contraindication, hormone replacement therapy (HRT...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

  • Patients with POI should be seen annually to manage HRT.

  • Endocrine and autoimmune testing should be initiated annually depending on the clinical findings (3).

  • Mamm...

REFERENCES

1
Hewlett  M, Mahalingaiah  S. Update on primary ovarian insufficiency. Curr Opin Endocrinol Diabetes Obes.  2015; 22(6): 483– 489.  [View ...

ADDITIONAL READING

  • Committee on Gynecologic Practice. Committee Opinion No. 698: hormone therapy in primary ovarian insufficiency. Obstet Gynecol. 2017;129:e134-141.

  • ...

CODES

ICD10

  • E28.9 Ovarian dysfunction, unspecified

  • E28.39 Other primary ovarian failure

  • Q96.9 Turner's syndrome, unspecified

  • E28.319 Asymptomatic premature menopause

SNOMED

  • 65846009 Primary ovarian failure ...

CLINICAL PEARLS

  • POI is not the same as premature menopause: Patients with POI can experience spontaneous pregnancy.

  • Unless there is an absolute contraindication, those affected should be on HRT to main...

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