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Primary Ovarian Insufficiency

Reviewed 06/2019
 


BASICS

DESCRIPTION

  • Primary ovarian insufficiency (POI) is used to describe a spectrum of conditions including hypergonadotropic hypogonadism, premature ovarian failure (POF), and ovarian dysgenesis in ...

DIAGNOSIS

HISTORY

  • Oligomenorrhea. Typically, history of normal puberty and menses, although primary amenorrhea and absence of secondary sexual characteristics is present in 10–30% of cases. May also ex...

TREATMENT

GENERAL MEASURES

  • Medical treatment should address patient’s hormonal, reproductive, emotional, and psychological needs.

  • Referral for psychological and emotional support may be necessary.

  • Unless...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

  • Patient with POI should be seen annually to manage HRT.

  • Endocrine and autoimmune testing should be initiated annually depending on the clinical findings (3).

Patient Monitoring

REFERENCES

1
Hewlett M, Mahalingaiah S. Update on primary ovarian insufficiency. Curr Opin Endocrinol Diabetes Obes.  2015;22(6):483–489. [View Abstract on OvidMedline]
2
Committee on Adolescent Hea...

ADDITIONAL READING

National Collaborating Centre for Women’s and Children’s Health. Menopause: Full Guideline. London, United Kingdom: National Institute for Health and Care Excellence; 2015. [View ...

CODES

ICD10

  • E28.9 Ovarian dysfunction, unspecified

  • E28.39 Other primary ovarian failure

  • Q96.9 Turner’s syndrome, unspecified

  • E28.319 Asymptomatic premature menopause

ICD9

  • 256.9 Unspecified ovarian dysfuncti...

CLINICAL PEARLS

  • POI is not the same as premature menopause: Patients with POI can experience spontaneous pregnancy.

  • Unless there is an absolute contraindication, those affected should be on HRT to main...

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