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Nephrocalcinosis

G. Rajashekar, MBBS, Asif Ansari, MD, MRCP, FACP, FASN and Narothama Reddy Aeddula, MD, FACP, FASN Reviewed 06/2019
 


BASICS

DESCRIPTION

  • Nephrocalcinosis (NC) is a condition in which there is deposition of calcium in the renal parenchyma and tubules.

  • NC refers to the deposition of both calcium phosphate and calcium oxa...

DIAGNOSIS

HISTORY

  • Preterm birth

  • Polyuria and polydipsia

  • Hematuria

  • Renal colic

  • Past medical history of nephrolithiasis, vesicoureteric reflux, recurrent UTIs

  • Family history of nephrolithiasis, cystic kidney ...

TREATMENT

GENERAL MEASURES

  • Manage or prevent hypercalcemia.

  • Address hyperparathyroidism or other underlying cause.

  • In setting of preserved renal function, decrease solute concentration in the urine by ma...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Based on etiology and comorbidities 

Patient Monitoring

  • Based on etiology

  • Patients often need ongoing trending of serum calcium, phosphate, uric acid, and renal func...

REFERENCES

1
Sayer JA, Carr G, Simmons NL. Nephrocalcinosis: molecular insights into calcium precipitation within the kidney. Clin Sci (Lond).  2004;106(6):549–561. [View Abstract on OvidMedline]
2
...

ADDITIONAL READING

  • Huynh M, Clark R, Li J, et al. A case control analysis investigating risk factors and outcomes for nephrocalcinosis and renal calculi in neonates. J Pediatr Urol.  2017;13(4):3...

CODES

ICD10

  • E83.59 Other disorders of calcium metabolism

  • N29 Oth disorders of kidney and ureter in diseases classd elswhr

ICD9

275.49 Other disorders of calcium metabolism 

SNOMED

  • 48638002 nephrocalcinosis ...

CLINICAL PEARLS

  • NC is often found incidentally on imaging.

  • NC should be considered a sign of another disease process, more than it should be considered a disease process itself (3).

  • NC is most common in...

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