Intrahepatic cholestasis of pregnancy (ICP) is the most common pregnancy-specific liver disorder characterized by new-onset pruritus that often starts on the palms and soles before b...
Pruritus that is worse at night, improved with cold temperatures, and progressive with advancing gestational age (1,2)
Onset of pruritus often precedes the elevation in bile acids (2...
Repeat serum bile acid levels and liver function tests 6 to 12 weeks after delivery.
Persistent lab abnormalities or symptoms necessitate gastroenterology referral...
Brouwers L, Koster MP, Page-Christiaens GC, et al. Intrahepatic cholestasis of pregnancy: maternal and fetal outcomes associated with elevated bile aci...
K83.1 Obstruction of bile duct
O26.619 Liver and biliary tract disord in pregnancy, unsp trimester
O26.611 Liver and biliary tract disord in pregnancy, first trimester
O26.612 Liver and biliar...
Consider ICP in pregnant women with diffuse itching in the absence of rash.
Serum bile acids are the most sensitive laboratory test for ICP, but liver function tests may also be abnorma...
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