Skip to main content

Cryptogenic Organizing Pneumonia

Maggie C. Wertz, MD and Anne Marie Kennedy, DO Reviewed 06/2019
 


BASICS

DESCRIPTION

  • Cryptogenic organizing pneumonia or COP is the idiopathic inflammatory process of diffuse interstitial granulation extending to the distal airways and alveoli.

  • As opposed to secondary...

DIAGNOSIS

Consider COP and the differential diagnoses in patients presenting with: 
  • Flulike illness that lasts 4 to 10 weeks or longer. Most have been treated with empiric antibiotics without success.

  • F...

TREATMENT

  • Has not been studied in randomized trials; regimens based on practice guidelines, case series, and clinical judgment

  • Observation for patients with minimal symptoms, mild radiographic involvem...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

  • Frequent visits, weekly at first

  • Prednisone must be continued because of the chance of relapse. While on prednisone, monitor:

    • CXR and PFT every ...

REFERENCES

1
Cottin V, Cordier JF. Cryptogenic organizing pneumonia. Semin Respir Crit Care Med.  2012;33(5):462–475. [View Abstract on OvidMedline]
2
Marchiori E, Zanetti G, Hochhegger B, et al. Re...

ADDITIONAL READING

  • Cordier JF. Cryptogenic organising pneumonia. Eur Respir J.  2006;28(2):422–446. [View Abstract on OvidMedline]

  • Kavakli K, Ocal N, Dogan D, et al. Is there any superiority among...

CODES

ICD10

J84.116 Cryptogenic organizing pneumonia 

ICD9

516.36 Cryptogenic organizing pneumonia 

SNOMED

129458007 Bronchiolitis obliterans organizing pneumonia (disorder) 

CLINICAL PEARLS

  • COP is an idiopathic restrictive problem that is completely reversible in most cases.

  • Major risk factors for COP include immunosuppression; no known association with smoking

  • Consider COP...

Subscribe to Access Full Content

Sign Up for a 10-Day Free Trial

Sign up for a 10-day FREE Trial now and receive full access to all content.

×