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Cryptogenic Organizing Pneumonia

Daniel R. Matta, MD and Alexis Jibril, Master?s of Public Health, Medical Doctorate Reviewed 06/2022
 


BASICS

DESCRIPTION

  • Cryptogenic organizing pneumonia (COP) is a subclassification of idiopathic interstitial pneumonia (1).

  • It is an inflammatory process of the distal airways and alveoli with diffuse i...

DIAGNOSIS

Consider COP and the differential diagnoses in patients presenting with: 
  • Flulike illness that lasts 4 weeks or longer

  • Fatigue, fever, and weight loss >10 lb

  • Persistent nonproductive cough

  • Bi...

TREATMENT

  • Treatments have not been studied in randomized trials. Regimens are based on practice guidelines, case series, and clinical judgment.

  • Mild stable disease: Minimal symptoms and normal or borde...

ONGOING CARE

Resolution after proper treatment 

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

  • Frequent visits

  • ​​​​Counseling on compliance of steroid use at every visit

  • Monitor lung disease and side effects...

REFERENCES

1
Travis WD, Costabel U, Hansell DM, et al. An official American Thoracic Society/European Respiratory Society statement: Update of the international multidisciplinary classification of the ...

ADDITIONAL READING

  • Jara-Palomares L, Gomez-Izquierdo L, Gonzalez-Vergara D, et al. Utility of high-resolution computed tomography and BAL in cryptogenic organizing pneumonia.  R...

CODES

ICD10

J84.116 Cryptogenic organizing pneumonia 

SNOMED

129458007 Bronchiolitis obliterans organizing pneumonia (disorder) 

CLINICAL PEARLS

  • COP is an idiopathic interstitial pneumonia that is reversible in most cases.

  • There are no known major risk factors for COP.

  • Consider COP in prolonged respiratory illness with fatigue, n...

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