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Immune Thrombocytopenia (ITP)

Pedro Emilio Alcedo, MD, Gabriela Sanchez Petitto, MD and Cristhiam Rojas-Hernandez, MD Reviewed 06/2019
 


BASICS

DESCRIPTION

  • Immune thrombocytopenia (ITP) is a condition characterized by the immunologic destruction of normal platelets and/or impaired thrombopoiesis in response to an unknown stimulus.

  • It is ...

DIAGNOSIS

A careful history, physical exam, and review of CBC and peripheral blood smear remain the key components of the diagnosis of ITP. 

HISTORY

  • Often asymptomatic; found incidentally on routine CBC

  • ...

TREATMENT

GENERAL MEASURES

  • Management is based on both platelet count and hemorrhagic manifestations.

  • Current evidence-based guidelines recommend treatment should be administered for newly diagnosed pat...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

Platelet counts weekly for patients on prednisone and monthly for stable patients are reasonable. 

DIET

  • Evidence demonstrating benefit of an anti-...

REFERENCES

1
Neunert C, Lim W, Crowther M, et al; for American Society of Hematology. The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia. Blood.  ...

CODES

ICD10

D69.3 Immune thrombocytopenic purpura 

ICD9

287.31 Immune thrombocytopenic purpura 

SNOMED

  • 234490009 Immune thrombocytopenic purpura (disorder)

  • 32273002 Idiopathic thrombocytopenic purpura (diso...

CLINICAL PEARLS

  • ITP: platelet counts of <100 × 109/L caused by accelerated destruction and/or impaired thrombopoiesis by antiplatelet antibodies

  • Pediatric ITP: relatively common, with spontaneous re...

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