Skip to main content

Stevens-Johnson Syndrome

Tran K. Nguyen, MD, Cristian P. Fernandez Falcon, MD, DABFM, CAQGM, CAQHPM, CMD and Valerie F. Davis Barnabas, MD Reviewed 06/2019
 


BASICS

DESCRIPTION

  • A generalized hypersensitivity reaction, usually to a drug, in which skin and mucous membrane lesions are an early manifestation

  • Once considered on the same spectrum with erythema mul...

DIAGNOSIS

HISTORY

  • A preceding illness for which medication was prescribed, typically 1 to 3 weeks before initial cutaneous manifestations

  • Sudden onset with rapidly progressive pleomorphic rash that incl...

TREATMENT

GENERAL MEASURES

  • Withdraw potentially offending medications, and treat any underlying disease.

  • Meticulous skin care; similar to burn patients

  • Supportive care, including moisture-retentive ointm...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

  • Document all offending/suspected agents.

  • Education to limit exposure to offending/suspected medications/chemical agents

DIET

IV nutritional support with increased pr...

REFERENCES

1
Struck MF, Hilbert P, Mockenhaupt M, et al. Severe cutaneous adverse reactions: emergency approach to non-burn epidermolytic syndromes. Intensive Care Med.  2010;36(1):22–32. [View Ab...

SEE ALSO

Burns; Cutaneous Drug Reactions; Dermatitis Herpetiformis; Erythema Multiforme; Pemphigoid, Bullous; Pemphigus Vulgaris; Respiratory Distress Syndrome, Acute (ARDS) 

CODES

ICD10

  • L51.1 Stevens-Johnson syndrome

  • L51.3 Stevens-Johnson synd-tox epdrml necrolysis overlap syndrome

ICD9

  • 695.13 Stevens-Johnson syndrome

  • 695.14 Stevens-Johnson syndrome-toxic epidermal necrolysis ...

CLINICAL PEARLS

  • SJS and TEN are a delayed-hypersensitivity medication reaction.

  • SJS is a medical emergency.

  • Corticosteroid treatment is controversial. If chosen and no response within 1st few days, disc...

Subscribe to Access Full Content

Sign Up for a 10-Day Free Trial

Sign up for a 10-day FREE Trial now and receive full access to all content.

 
×