Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)

A syndrome of abnormal production of antidiuretic hormone (ADH), despite low serum osmolality, leading to hyponatremia and inappropriately elevated urine osmolality

• Decreased urinary ...

Fatigue

Anorexia

Nausea

Vomiting

Diarrhea

Headaches

Unsteady gait

Falls

Myalgias/weakness

Increased thirst

Confusion

Seizures, coma

Euvolemic state

Mild hyponatremia (serum ...

Treatment of the underlying cause is essential.

Requires frequent monitoring (see “Patient Monitoring”)

Fluid restriction (usually <1,000 mL/day) is the main treatment (2)[B...

Careful continuous clinical and laboratory monitoring of hyponatremic state during acute phase:

• Hourly urine output

• Urine Na, urine potassium, uri...

Treatment of the underlying cause is a key. Review all medications for potential culprits.

Fluid restriction is the mainstay of treatment in SIADH. Fluid restriction fails to correct hy...