Multidrug-resistant tuberculosis (MDR-TB) is disease that is resistant to first-line medications: isoniazid, pyrazinamide, streptomycin, ethambutol, and rifampin.
Prior positive purified protein derivative (PPD) test, TB treatment, TB exposure, travel to an area where TB is endemic, homelessness, or incarceration
Begin empiric TB treatment with a four-drug regimen (pending culture and sensitivities): isoniazid, rifampin, pyrazinamide, either ethambutol or streptomycin. The fourth drug...
Follow the patient 2 years after completing treatment.
Close contacts may need prophylaxis as per infectious disease recommendations.
Consider TB/MDR-TB for any patient presenting with an infectious lung process, particularly with hemoptysis.
Start empiric therapy prior to sputum culture results if TB is suspected.
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