Multidrug-Resistant Tuberculosis

Multidrug-resistant tuberculosis (MDR-TB) is disease that is resistant to first-line medications: isoniazid, pyrazinamide, streptomycin, ethambutol, and rifampin.

Extensively, drug-re...

Sexual history

Prior positive purified protein derivative (PPD) test, TB treatment, TB exposure, travel to an area where TB is endemic, homelessness, or incarceration

Dyspnea

Chest pain

H...

Begin empiric TB treatment with a four-drug regimen (pending culture and sensitivities): isoniazid, rifampin, pyrazinamide, either ethambutol or streptomycin. The fourth drug...

Follow the patient 2 years after completing treatment.

Close contacts may need prophylaxis as per infectious disease recommendations.

Consider TB/MDR-TB for any patient presenting with an infectious lung process, particularly with hemoptysis.

Start empiric therapy prior to sputum culture results if TB is suspected.

Fiv...