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Pick Disease

Bassem M. Mostafa Elsawy, MD FAAFP AGSF and Dalton Allen Reviewed 06/2021
 


BASICS

DESCRIPTION

  • A type of progressive frontotemporal dementia (FTD) typically affecting the frontal and/or anterolateral temporal lobes

  • Named after Dr. Arnold Pick, the psychiatrist/neuropathologist ...

DIAGNOSIS

Diagnostic Criteria: 
  • Behavioral variant (bv):

    • Possible bvFTD requires 3 of 6 of the following features: disinhibition, apathy/inertia, loss of sympathy/empathy, perseverative/compul...

TREATMENT

GENERAL MEASURES

  • There is no specific treatment for Pick disease because no medication is available that has been shown to arrest or reverse this condition. Medicines can be used to treat the...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Require periodic follow-up care to address behavioral problems, reevaluate the diagnosis if questionable, tailor pharmacologic treatments, and provide caregiver s...

REFERENCES

1
Graham  A, Hodges  J. Frontotemporal dementia. Psych.  2008;7(1):24–28. [View Abstract on OvidMedline]
2
Forman  MS, F...

ADDITIONAL READING

  • Cardarelli R, Kertesz A, Knebl J, et al. Frontotemporal Dementia: A Review for Primary Care Physicians. Am Fam Physician. 2010;82(11):1372-1377.

  • ...

CODES

ICD10

  • G31.01 Pick’s disease

  • G31.09 Other frontotemporal dementia

SNOMED

  • 13092008 Pick’s disease

  • 230270009 Frontotemporal dementia

  • 21921000119103 Dementia due to Pick’s disease

  • 230288001 Semantic dement...

CLINICAL PEARLS

  • When dementia occurs early (in midlife), especially if associated with personality and behavioral changes, consideration should be given to the possible diagnosis of Pick disease.

  • Cogni...

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