Pick Disease

Reviewed 06/2019

BASICS

DESCRIPTION

A type of progressive frontotemporal dementia typically affecting the frontal and/or anterolateral temporal lobes
Named after Dr. Arnold Pick, the psychiatrist/neuropathologist who de...

DIAGNOSIS

HISTORY

Changes in language, speech, or personality/behavior
Memory impairment can also occur but tends to be less severe.
Incontinence can occur.
Parkinsonism (such as rigidity and gait abnorma...

TREATMENT

GENERAL MEASURES

There is no specific treatment for Pick disease because no medication is available that has been shown to arrest or reverse this condition. Medicines can be used to treat the...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Require periodic follow-up care to address behavioral problems, reevaluate the diagnosis if questionable, tailor pharmacologic treatments, and provide caregiver s...

REFERENCES

Graham A, Hodges J. Frontotemporal dementia. Psych. 2008;7(1):24–28. [View Abstract on OvidMedline]

Forman MS, Farmer J, Johnson JK, et al. Frontotemporal dementia: clinicopathologic...

ADDITIONAL READING

Pick A. Ueber die Beziehungen der senilen Hirnatrophie zur Aphasie [in German]. Prager Medicinische Wochenschrift. 1892;17:165–167. [View Abstract on OvidMedline]

CODES

ICD10

G31.01 Pick’s disease
G31.09 Other frontotemporal dementia

ICD9

331.11 Pick’s disease
331.19 Other frontotemporal dementia

SNOMED

13092008 Pick’s disease
230270009 Frontotemporal dementia
219210001...

CLINICAL PEARLS

When dementia occurs early (in midlife), especially if associated with personality and behavioral changes, consideration should be given to the possible diagnosis of Pick disease.
Cogni...

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