The term for localized scleroderma is morphea, which is derived from the Greek word for “form” or “structure.” Fibrosis is characteristic and may involve the skin, subcutaneous (SC) ...
General concepts:
Fibrosis limited to skin, SC tissue, muscle, and bone
Systemic features including Raynaud phenomenon and true visceral fibrosis should prompt reconsideration of ...
Differentiating disease activity (inflammation) and damage (fibrosis) has important implications for therapy: Disease activity responds to therapy but longstanding disease damage does n...
Once systemic immunosuppressive therapy is initiated, disease activity typically begins to resolve within months, and features of damage may als...
201048007 Localized scleroderma
201049004 Morphea
403522004 Subcutaneous morphea
403521006 Guttate morphea
227840...
Li SC, Torok KS, Pope E, et al; and Childhood Arthritis and Rheumatology Research Alliance (CARRA) Localized Scleroderma Workgroup. Development of consensus treatment plans for juve...
Q: Is a biopsy necessary?
A: Biopsy is often useful primary to evaluate for the extent of disease activity (lymphoplasmacytic infiltrate) versus damage (homogenized collagen and fibrosis) and to ex...
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