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Sepsis, Neonatal, Pediatric

Julia Johnson, MD and Azadeh Farzin, MD, MHS Reviewed 10/2018
 


BASICS

DESCRIPTION

  • Clinical syndrome characterized by systemic infection occurring within the first 28 days of life

  • Early-onset sepsis (EOS) and late-onset sepsis (LOS) occur within and following the fi...

DIAGNOSIS

HISTORY

  • Thorough pregnancy, labor, and delivery history to elicit presence of risk factors

  • Change in behavior or level of alertness

  • Poor feeding

  • Decreased urinary output

  • Family history of sibling...

TREATMENT

GENERAL MEASURES

Supportive measures should focus on monitoring and treatment of associated comorbidities, including cardiorespiratory compromise and temperature instability. 

MEDICATION

  • Goal o...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

In cases of end-organ dysfunction, consider additional follow-up with appropriate subspecialty and support services, including a developmental specialist and occu...

ADDITIONAL READING

  • Benitz WE, Wynn JL, Polin RA. Reappraisal of guidelines for management of neonates with suspected early-onset sepsis. J Pediatr.  2015;166(4):1070–1074. [View Abstract on OvidI...

CODES

ICD9

995.91 Sepsis 

ICD10

  • A41.9 Sepsis, unspecified organism

  • P36.9 Bacterial sepsis of newborn, unspecified

SNOMED

  • 206376005 Sepsis of the newborn

  • 91302008 Sepsis

  • 276669000 Bacterial sepsis of newborn

FAQ

  • Q: Are any decision-making tools available to providers evaluating neonates for sepsis?

  • A: In neonates born at ≥34 weeks’ gestation, the risk of EOS can be calculated using the Neonatal Sepsis Calc...

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