Calcium pyrophosphate deposition disease (CPPD) is a crystal arthropathy characterized by deposition of calcium pyrophosphate (CaPPi) dihydrate crystals in joints.
Synonym(s):
Pseudogo...
Acute joint swelling in one or more joints with previous episodes involving the same joint (characteristic of crystal arthropathies)
The most common joint is the knee, followed by the ...
Acute treatment:
Joint aspiration often significantly reduces pain 7[C].
Intra-articular corticosteroid injection can be effective 8[C].
Joint rest and splinting if needed
Nonsteroidal anti-infl...
Primary metabolic disorders or familial predisposition is uncommon but should be considered if CPPD occurs before 55 yr of age or if there is florid polyarticular CPPD.
After the age of 55...
Courtney P, Doherty M. Joint aspiration and injection and synovial fluid analysis. Best Pract Res Clin Rheumatol. 2013;27(2):137–169.
Couto AR, Brown MA. Genetic factors in the...
The cause of CPPD is unknown (unlike gout, in which hyperuricemia leads to precipitation of uric acid crystals into joints).
Aspiration of joint fluid is key to diagnosis.
There is no pr...
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