Primary effect is competitive inhibition of cyclooxygenase (COX) enzyme, thus inhibiting production of prostaglandins, thromboxanes, and prostacyclin from arachidonic acid.
There are two COX iso...
Although significant symptoms may occur after 5 to 10 times the maximum dose has been ingested, there is a poor correlation between the amount ingested and toxic poisoning.
Timing of i...
Call poison control.
Secure the ABCs.
There is no antidote for NSAID poisoning.
Close monitoring is warranted for almost all patients, and usually, this is t...
Hunter LJ, Wood DM, Dargan PI. The patterns of toxicity and management of acute nonsteroidal anti-inflammatory drug (NSAID) overdose. Open Access Emerg Med. 2011;3:39–48.
There is no additional benefit to giving >1 dose of activated charcoal.
Ipecac has fallen out of favor for most acute ingestions and is not recommended for NSAID toxicity.
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