Mpox (Orthopoxvirus sp.)

Sean C. Conley, D.O. Reviewed 05/2023

BASICS

DESCRIPTION

Mpox is a zoonotic disease caused by the Mpox virus—an enveloped, double-stranded DNA virus of the Orthopoxvirus genus and Poxviridae family.
Two clades have previously been described...

DIAGNOSIS

HISTORY

Patients may report:
- Fever, chills, malaise
- Headache
- Sore throat, congestion, cough
- Myalgias
- Rash that is often painful and/or pruritic

PHYSICAL EXAM

Exam findings include: ...

TREATMENT

GENERAL MEASURES

The patient should be instructed to isolate to avoid further spread until the rash is fully healed. Until then, keep the rash covered and avoid autoinoculation to other parts...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patients should be recommended to isolate and take other measures to prevent transmission until their rash has fully resolved

Patient Monitoring

Patients who have ...

REFERENCES

Centers for Disease Control and Prevention. Mpox. Retrieved November 3, 2022 from https://www.cdc.gov/poxvirus/Mpox/index.html.

Gessain A, Nakoune E, Yazdanpanah Y. Mpox. New Engl J Med. 2...

CLINICAL PEARLS

Patients who meet certain criteria for being at risk for Mpox are eligible for vaccination
Lymphadenopathy is a key differentiator in the differential diagnosis
Care for those with Mpox ...

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