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Antihemophilic Factor/von Willebrand Factor Complex (Human)



General

Pronunciation

(an tee hee moe FIL ik FAK tor von WILL le brand FAK tor KOM plex HYU man)

Brand Names: U.S.

  • Alphanate
  • Alphanate/VWF Complex/Human [DSC]
  • Humate-P
  • Wilate

Indications

Use: Labeled Indications

Hemophilia A:

Alphanate: Treatment and prevention of bleeding in adult and pediatric patients with factor VIII deficiency due to hemophilia A (classical hemophilia).

Humate-P: Treatment and prevention of bleeding in adults with hemophilia A (classical hemophilia).

Wilate: Treatment and prevention of bleeding in adults and pediatric patients ≥12 years of age with hemophilia A (classical hemophilia).

von Willebrand disease:

Alphanate: Surgical and/or invasive procedures in adult and pediatric patients with von Willebrand disease when desmopressin is either ineffective or contraindicated

Limitations of use: Not indicated for patients with severe von Willebrand disease (type 3) undergoing major surgery.

Humate-P: Treatment of spontaneous or trauma-induced bleeding, as well as prevention of excessive bleeding during and after surgery in adult and pediatric patients with severe von Willebrand disease, including mild or moderate von Willebrand disease where use of desmopressin is known or suspected to be inadequate.

Limitations of use: Safety and efficacy of prophylactic dosing to prevent spontaneous bleeding have not been conducted in patients with von Willebrand disease.

Wilate: On demand treatment and control of bleeding episodes, and perioperative management of bleeding in adult and pediatric patients with von Willebrand disease.

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