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Diazepam



General

Pronunciation

(dye AZ e pam)

Brand Names: U.S.

  • Diastat AcuDial
  • Diastat Pediatric
  • diazePAM Intensol
  • Valium
  • Valtoco 10 MG Dose
  • Valtoco 15 MG Dose
  • Valtoco 20 MG Dose
  • Valtoco 5 MG Dose

Indications

Use: Labeled Indications

Alcohol withdrawal syndrome (oral and injection): Symptomatic relief of acute agitation, tremor, impending or acute delirium, delirium tremens, and hallucinosis associated with alcohol withdrawal.

Anxiety, acute/severe (oral and injection): Short-term relief of severe anxiety symptoms.

Anxiety disorders (oral and injection): Management of anxiety disorders.

Muscle spasm, spasticity, and/or rigidity (oral and injection): As an adjunct for the relief of skeletal muscle spasm due to reflex spasm caused by local pathology (eg, inflammation of muscles or joints, secondary to trauma); spasticity caused by upper motor neuron disorders (eg, cerebral palsy, paraplegia); athetosis; stiff-man syndrome; and tetanus.

Procedural anxiety, premedication (injection): Relief of anxiety and tension in patients undergoing surgical procedures; prior to cardioversion for the relief of anxiety and tension and to diminish patient's recall (IV only); as an adjunct prior to endoscopic procedures for apprehension, anxiety, or acute stress reactions and to diminish patient's recall.

Note: Use of diazepam in patients undergoing cardioversion or endoscopic procedures has been superseded by agents with a more pharmacokinetically favorable profile (eg, midazolam) (Thomas 2014; Triantafillidis 2013).

Seizures, acute, active: Adjunct in convulsive disorders (oral); management of select, refractory epilepsy patients on stable regimens of antiepileptic drugs requiring intermittent use of diazepam to control episodes of increased seizure activity (rectal); treatment of intermittent, stereotypic episodes of frequent seizure activity (ie, seizure clusters, acute repetitive seizures) that are distinct from a patient's usual seizure pattern in patients with epilepsy (intranasal); adjunct in severe recurrent convulsive seizures (injection).

Status epilepticus (injection): Adjunct in status epilepticus.

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