GI disorders:
Aid in the control of acute episodes of gastric secretion, visceral spasm, hypermotility in spastic colitis, pylorospasm, and associated abdominal cramps; relieve symptoms in functional intestinal disorders (eg, mild dysenteries, diverticulitis) and infant colic.
Adjunctive therapy for treatment in peptic ulcer; irritable bowel syndrome (IBS) (irritable colon, spastic colon, acute enterocolitis, mucous colitis) and other functional GI disorders; neurogenic bowel disturbances (including splenic flexure syndrome and neurogenic colon).
Limitations of use: The American College of Gastroenterology guideline on the management of IBS recommends against the use of antispasmodics, including hyoscyamine, for treatment of global symptoms of IBS (ACG [Lacy 2021]); however, some experts consider as-needed use beneficial for relief of abdominal pain associated with IBS (Wald 2021).