Delayed puberty: IM injection (enanthate); pellet: To stimulate puberty in carefully selected males with delayed puberty.
Hypogonadism, male (primary or hypogonadotropic): Buccal; Capsule (oral); Gel (nasal, transdermal); IM injection (cypionate, enanthate, undecanoate); Patch (transdermal); Pellet; Solution (transdermal); SubQ injection (Xyosted): Treatment of testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome, orchiectomy, Klinefelter syndrome, chemotherapy, or toxic damage from alcohol or heavy metals; gonadotropin or luteinizing hormone-releasing hormone deficiency; or pituitary-hypothalamic injury from tumors, trauma, or radiation.
Limitations of use: Safety and efficacy in men with age-related hypogonadism (or late-onset hypogonadism) have not been established (manufacturer's labeling). However, the Endocrine Society recommends offering testosterone therapy to patients with symptoms of testosterone deficiency and consistently and unequivocally low morning testosterone concentrations. In males >65 years of age, treatment should only be initiated on an individual basis and after consultation with the patient regarding risks and benefits (ES [Bhasin 2018]).